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Développement du Programme Educatif Fédéral et du Football Féminin au sein Club (H/F)

FOOTBALL CLUB D'HINGES

Publiée le 22/06/2025

Contrat

Service Civique

Localisation

Hinges (62)

Missions

Afficher les missions

Au sein de l'équipe, les actions principales du·de la volontaire sont les suivantes :

Promouvoir et valoriser le PEF au sein du club sous la responsabilité du référent PEF . Mettre en place des activités, ateliers permettant de sensibiliser les enfants aux valeurs de plaisir, respect, tolérance, solidarité et engagement . Aider à développer les valeurs du club à travers 6 thématiques (santé, fairplay, culture foot, règles du jeu/arbitrage, engagement citoyen et environnement) . Participer à l’encadrement des entrainements en relation avec les actions. Candidatures ouvertes public féminin et masculin.

Promouvoir et Développer le Foot Féminin :

Aide dans les actions menés sur le terrain au développement féminin (journées portes ouvertes, découvertes du foot dans les écoles, aide aux éducateurs du foot féminin…)
Soutien à l’élaboration de la stratégie de communication autour des événements en lien avec le foot féminin.

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Post-doctoral position (F/H)

INSTITUT CURIE

Publiée le 07/10/2025

Contrat: CDD
Localisation: Paris (75)
Missions: Afficher les missions
Laboratory
The research group DNA repair mechanisms in cancers (Ceccaldi Lab, https://institut-curie.org/team/ceccaldi) is seeking a post-doctoral researcher driving cutting-edge research projects aiming at understanding the mechanisms regulating genome stability.
In the recent years, our team significant contributions to the field of genome stability and tumor biology. Focusing on compensatory mechanisms employed by cancer cells with defects in homologous recombination (HR) -mediated repair, we shed light on new mechanisms and pathways controlling genome stability and Homologous Recombination (HR) -deficient tumor survival.
From a translational point of view, our group has identified (and developed inhibitors against) new drug targets for the treatment of breast and ovarian tumors target and highlighted the importance of studying the relationships between the different DNA repair pathways to better understand their interaction and exploit them for therapeutic purposes. Our long-term research goals hinge on the critical need for 1) new scientific approaches to discover additional regulators and effectors of genome stability, 2) basic understanding of interconnections between DNA repair processes, and 3) new drug development and biomarkers for anticancer targeted therapy.
Missions
Our team is committed to developing innovative strategies to combat breast and ovarian cancers. Through high-throughput screening, we have identified small-molecule inhibitors targeting novel anti-cancer drug targets. We are now seeking a postdoctoral researcher to further develop these compounds and assess their antitumor efficacy in both in vitro and in vivo models, including organoids and patient-derived xenografts.
The successful candidate will benefit from access to a comprehensive collection of preclinical models established at Institut Curie. In addition, they will collaborate with chemists to optimize the inhibitor molecules and with crystallographers to uncover their mechanisms of action through co-crystallization studies.
Recent publications from the team
1. Ceccaldi R and Cejka P. Mechanisms and regulation of DNA End Resection in the Maintenance of Genome Stability. Nature Reviews Molecular Cell Biology, 2025.
2. Musiani, D. et al. SMUG1 trapping at unprocessed uracil upon UNG inhibition triggers homologous recombination and selectively kills BRCA1/2-deficient tumors. Molecular Cell, 2025.
3. Kovacs, M. T. et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Molecular Cell, 2023.
4. Gelot, C. et al. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis. Nature, 2023.
5. Zhou, J. et al. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nature Cancer, 2021.

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Développement du Programme Educatif Fédéral et du Football Féminin au sein Club (H/F)

DÉVELOPPEMENT DU PROGRAMME EDUCATIF FÉDÉRAL ET DU FOOTBALL FÉMININ AU SEIN CLUB (H/F)

Post-doctoral position (F/H)

POST-DOCTORAL POSITION (F/H)