Présentation

Qui sommes-nous ?

Nous sommes les Laboratoires Pierre Fabre, leader mondial qui allie expertise pharmaceutique et dermo-cosmétique pour accompagner les consommateurs et les patients à chaque étape de leur parcours de soins.
Notre portefeuille compte plusieurs franchises médicales et marques internationales dont Eau thermale Avène, Ducray, A-Derma, Klorane, René Furterer et Pierre Fabre Oral Care.
En nous rejoignant, vous intégrez une entreprise riche de sens, où la dimension humaine est essentielle. Vous devenez acteur du "We Care Movement", un mouvement qui valorise l'excellence et l'innovation au sein d'équipes passionnées. Ensemble, nous repoussons les limites de la science pour unir santé et beauté au bénéfice de tous, car à chaque fois que nous prenons soin d’une seule personne, nous rendons le monde meilleur.

Présents dans 120 pays et une équipe de plus de 10 000 collaborateurs, nous sommes fiers de créer un impact scientifique et humain, aujourd'hui et demain! Si prendre soin est au cœur de vos valeurs, rejoignez les Laboratoires Pierre Fabre et devenez un acteur clé du "We Care Movement".

Votre mission

We are seeking for the R&D Pharma in Toulouse a skilled Pharmacokinetics / Pharmacodynamics (PK/PD) Scientist to support our Dermatology, Oncology & Rare Diseases Drug Discovery portfolio.

The ideal candidate will prove expertise in PK/PD, with an understanding of dermatological biology, skin‑targeted drug delivery, and translational sciences. This role is critical in guiding decision‑making from early discovery through candidate selection.

The PK/PD Scientist will partner closely with discovery biology, medicinal chemistry, DMPK, toxicology, and clinical development teams to optimize compound selection, design robust translational strategies.

The incumbent will collaborate in AI& data‑driven development of innovative therapies, understanding of how AI‑derived properties relate to downstream outcomes (PK, efficacy, safety, human dose) .

Your role within a pioneering company in full expansion:

Cross‑Functional Collaboration & Leadership

• Serve as the PK/PD and/or PBPK representative on multidisciplinary project teams.
• Provide strategic input for compounds selection/prioritization, study design, assay prioritization, biomarker selection, and overall program strategy.
• Communicate modeling assumptions, results, and recommendations to scientific teams and senior decision‑makers.

PK/PD Modeling & Quantitative Sciences

• Characterize exposure–response relationships for efficacy, biomarkers, target engagement, and safety.
• Support dose and schedule optimization across modalities (small molecules, biologics, ADCs, topical/intradermal agents) .
• Integrate PK, PD, biomarker, and efficacy data to enable translational predictions and improve candidate selection.
• Support predictions of human PK, human effective dose and local vs systemic exposure.
• Use and refine PBPK models to project tissue distribution, including:
  • tumor penetration (oncology)
  • skin and dermal distribution (dermatology)
  • Contribute PBPK analyses to IND enabling packages and early clinical strategy.

Oncology Drug Discovery Support

• Implement quantitative frameworks for tumor growth inhibition (TGI) models and immune‑oncology mechanisms.
• Support MoA exploration, combination‑strategy modeling, and therapeutic index assessment.
• Translate preclinical PK/PD and/or PBPK findings into first‑in‑human guidance.

Dermatology Drug Discovery Support

• Apply PK/PD and/or PBPK approaches to understand cutaneous absorption, skin barrier penetration, and dermal pharmacokinetics.
• Support optimization of topical formulations, systemic agents with skin‑selective activity, and disease‑relevant biomarker strategies.
• Integrate skin PK according to patient population, lesion‑level response, and biomarker data to guide lead optimization.

Software, Data Handling & Documentation

• Use industry‑standard tools (e.g., Phoenix NLME) to perform high‑quality modeling and simulation.
• Ensure rigorous documentation and reproducibility of modeling workflows, results, and insights.
• Author internal documents (as needed) .

This position is compatible with teleworking up to 2 days a week according to company rules.

We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation…

Qui êtes-vous ?

Your skills at the service of innovative projects:

Previous experience (+5 years) in integrated solution combining PK/PD and/or PBPK expertise with direct oncology and dermatology support, including mechanistic understanding and translational alignment for oncology/dermatology-focused drug discovery programs.

In particular:

• Integration of PK/PD and or PBPK modeling and biomarker strategies essential for translational validity.
• Ability to support both early discovery (PoM/PoP) and (pre) clinical translation ensuring continuity across the development pipeline.
• Experience in Oncology, including TGI modeling, immune‑oncology PK/PD, or modeling for SM biologics/ADCs.
• Focus on discovery & preclinical models relevant to dermatology, including topical delivery, local tissue PK, and skin barrier modeling (e.g., human skin explants, iPSC-derived keratinocytes, in vivo inflammation models…) .
• Collaboration with experts familiar with AI/in silico ADMET, interpreting AI outputs in biological context , oncology/dermatology-specific pharmacology, inflammation, and PD biomarkers enhancing predictive power.
• bespoke PK/PD and/or PBPK modeling, linking complex preclinical experiments to (pre) clinical strategy.

La première richesse des Laboratoires Pierre Fabre, sont les femmes et les hommes qui les composent disait M. Pierre Fabre.

Fiers de cet héritage, et convaincus que la diversité des parcours, des expériences et des identités renforce notre performance collective, nous nous engageons à promouvoir l’égalité des chances et à garantir un environnement inclusif pour tous. Dans le respect des lois en vigueur, toutes les candidatures sont étudiées avec la même attention, sans distinction d’origine, de sexe, d’âge, de situation de handicap, d’orientation sexuelle, d’identité de genre, de croyances ou de toute autre caractéristique protégée par la loi.